Recent developments have shown that proteins can undergo a diverse range of modifications by lipid which can dramatically effect their structural and functional properties. These modifications include acylation, isoprenylation, and the attachment of glycolipid. Lipid modifications of proteins play important roles in cellular signalling, protein targeting and cellular growth and differentiation - the enzymes which catalyse these reactions are alreadt being seen as novel therapeutic targets. The biochemical, cell biological, and molecular biological techniques being used in this rapidly expanding field are becoming increasingly sophisticated. Lipid Modification of Proteins: A Practical Approach is a unique guide to the latest methods in use, written by the acknowledged experts in the field. Detailed protocols are provided for all the key techniques, and the relevant background material is included. This book will be an essential manual for a wide range of scientists studying the modification of protein by lipids, including membrane and protein biochemists, cell biologists, immunologists, bacteriologists, parasitologists, and virologists.
